Publications

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Principles and methods for transferring polygenic risk scores across global populations

Linda Kachuri, Nilanjan Chatterjee, Jibril Hirbo, Daniel J. Schaid, Iman Martin, ..., Ying Wang, Haoyu Zhang, Yuji Zhang, John S. Witte, Tian Ge

Nature Reviews Genetics   ·   24 Aug 2023   ·   doi:10.1038/s41576-023-00637-2

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2023

Principles and methods for transferring polygenic risk scores across global populations

Linda Kachuri, Nilanjan Chatterjee, Jibril Hirbo, Daniel J. Schaid, Iman Martin, ..., Ying Wang, Haoyu Zhang, Yuji Zhang, John S. Witte, Tian Ge

Nature Reviews Genetics   ·   24 Aug 2023   ·   doi:10.1038/s41576-023-00637-2

You can manually describe publications with markdown in sources.yaml. By specifying your orchid id in orchid.yaml, the website can also automatically find your publications. Highlighted manuscripts are defined in publications/index.md

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prs ancestry

Genetically adjusted PSA levels for prostate cancer screening

Linda Kachuri, Thomas J. Hoffmann, Yu Jiang, Sonja I. Berndt, John P. Shelley, ..., David V. Conti, Robert J. Klein, Jonathan D. Mosley, Rebecca E. Graff, John S. Witte

Nature Medicine   ·   01 Jun 2023   ·   doi:10.1038/s41591-023-02277-9

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Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture

Linda Kachuri, Angel C. Y. Mak, Donglei Hu, Celeste Eng, Scott Huntsman, ..., Noah A. Zaitlen, L. Keoki Williams, Christopher R. Gignoux, Esteban González Burchard, Elad Ziv

Nature Genetics   ·   25 May 2023   ·   doi:10.1038/s41588-023-01377-z

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Transcriptome-Wide Association Analysis Identifies Novel Candidate Susceptibility Genes for Prostate-Specific Antigen Levels in Men Without Prostate Cancer

Dorothy M. Chen, Ruocheng Dong, Linda Kachuri, Thomas Hoffmann, Yu Jiang, ..., David V. Conti, Robert J. Klein, Jonathan D. Mosley, John S. Witte, Rebecca E. Graff

Cold Spring Harbor Laboratory   ·   05 May 2023   ·   doi:10.1101/2023.05.04.23289526

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Supplementary Data from A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility

Nima C. Emami, Taylor B. Cavazos, Sara R. Rashkin, Clinton L. Cario, Rebecca E. Graff, ..., Catherine Schaefer, Neil Risch, Thomas J. Hoffmann, Stephen K. Van Den Eeden, John S. Witte

American Association for Cancer Research (AACR)   ·   31 Mar 2023   ·   doi:10.1158/0008-5472.22428541

Supplementary Data from A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility

Nima C. Emami, Taylor B. Cavazos, Sara R. Rashkin, Clinton L. Cario, Rebecca E. Graff, ..., Catherine Schaefer, Neil Risch, Thomas J. Hoffmann, Stephen K. Van Den Eeden, John S. Witte

American Association for Cancer Research (AACR)   ·   31 Mar 2023   ·   doi:10.1158/0008-5472.22428541.v1

Data from A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility

Nima C. Emami, Taylor B. Cavazos, Sara R. Rashkin, Clinton L. Cario, Rebecca E. Graff, ..., Catherine Schaefer, Neil Risch, Thomas J. Hoffmann, Stephen K. Van Den Eeden, John S. Witte

American Association for Cancer Research (AACR)   ·   31 Mar 2023   ·   doi:10.1158/0008-5472.c.6513064

Data from A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility

Nima C. Emami, Taylor B. Cavazos, Sara R. Rashkin, Clinton L. Cario, Rebecca E. Graff, ..., Catherine Schaefer, Neil Risch, Thomas J. Hoffmann, Stephen K. Van Den Eeden, John S. Witte

American Association for Cancer Research (AACR)   ·   31 Mar 2023   ·   doi:10.1158/0008-5472.c.6513064.v1

2022

Genetically Adjusted PSA Levels for Prostate Cancer Screening

Linda Kachuri, Thomas J. Hoffmann, Yu Jiang, Sonja I. Berndt, John P. Shelley, ..., David V. Conti, Robert J. Klein, Jonathan D. Mosley, Rebecca E. Graff, John S. Witte

Cold Spring Harbor Laboratory   ·   21 Apr 2022   ·   doi:10.1101/2022.04.18.22273850

Inverted genomic regions between reference genome builds in humans impact imputation accuracy and decrease the power of association testing

Xin Sheng, Lucy Xia, David V. Conti, Christopher A. Haiman, Linda Kachuri, Charleston W. K. Chiang

Cold Spring Harbor Laboratory   ·   20 Feb 2022   ·   doi:10.1101/2022.02.19.481174

Assessment of Genetic Susceptibility to Multiple Primary Cancers through Whole-Exome Sequencing in Two Large Multi-Ancestry Studies

Taylor B. Cavazos, Linda Kachuri, Rebecca E. Graff, Jovia L. Nierenberg, Khanh K. Thai, ..., Elad Ziv, Laurie Habel, Eric Jorgenson, Lori C. Sakoda, John S. Witte

Cold Spring Harbor Laboratory   ·   15 Feb 2022   ·   doi:10.1101/2022.02.11.22270688

2021

Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia

Linda Kachuri, Soyoung Jeon, Andrew T. DeWan, Catherine Metayer, Xiaomei Ma, John S. Witte, Charleston W.K. Chiang, Joseph L. Wiemels, Adam J. de Smith

The American Journal of Human Genetics   ·   01 Oct 2021   ·   doi:10.1016/j.ajhg.2021.08.004

The immunogenetics of viral antigen response is associated with sub-type specific glioma risk and survival

Geno Guerra, Linda Kachuri, George Wendt, Helen M. Hansen, Steven J. Mack, ..., Nori Kasahara, Jeanette E Eckel-Passow, Robert B. Jenkins, Margaret Wrensch, Stephen S. Francis

Cold Spring Harbor Laboratory   ·   16 Sep 2021   ·   doi:10.1101/2021.09.13.21263349

Genetic Factors Associated with Prostate Cancer Conversion from Active Surveillance to Treatment

Yu Jiang, Travis J. Meyers, Adaeze A. Emeka, Lauren Folgosa Cooley, Phillip R. Cooper, ..., Brian T. Helfand, Jianfeng Xu, Denise M. Scholtens, William J. Catalona, John S. Witte

Cold Spring Harbor Laboratory   ·   31 Aug 2021   ·   doi:10.1101/2021.08.30.21262305

Gene expression in African Americans and Latinos reveals ancestry-specific patterns of genetic architecture

Linda Kachuri, Angel C.Y. Mak, Donglei Hu, Celeste Eng, Scott Huntsman, ..., Noah A. Zaitlen, L. Keoki Williams, Christopher R. Gignoux, Esteban González Burchard, Elad Ziv

Cold Spring Harbor Laboratory   ·   19 Aug 2021   ·   doi:10.1101/2021.08.19.456901

Genetic Determinants of Blood Cell Traits Influence Susceptibility to Childhood Acute Lymphoblastic Leukemia

Linda Kachuri, Soyoung Jeon, Andrew T. DeWan, Catherine Metayer, Xiaomei Ma, John S. Witte, Charleston W. K. Chiang, Joseph L. Wiemels, Adam J. de Smith

Cold Spring Harbor Laboratory   ·   23 Apr 2021   ·   doi:10.1101/2021.04.17.21255679

2020

A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility

Nima C. Emami, Taylor B. Cavazos, Sara R. Rashkin, Clinton L. Cario, Rebecca E. Graff, ..., Catherine Schaefer, Neil Risch, Thomas J. Hoffmann, Stephen K. Van Den Eeden, John S. Witte

Cancer Research   ·   08 Dec 2020   ·   doi:10.1158/0008-5472.CAN-20-2635

Insecticide use and risk of non‐Hodgkin lymphoma subtypes: A subset meta‐analysis of the North American Pooled Project

Linda Kachuri, Laura E. Beane Freeman, John J. Spinelli, Aaron Blair, Manisha Pahwa, ..., Punam Pahwa, James A. Dosman, John R. McLaughlin, Paul A. Demers, Shelley A. Harris

International Journal of Cancer   ·   31 Jul 2020   ·   doi:10.1002/ijc.33164

The landscape of host genetic factors involved in immune response to common viral infections

Linda Kachuri, Stephen S. Francis, Maike Morrison, George A. Wendt, Yohan Bossé, Taylor B. Cavazos, Sara R. Rashkin, Elad Ziv, John S. Witte

Cold Spring Harbor Laboratory   ·   07 May 2020   ·   doi:10.1101/2020.05.01.20088054

Association Study of Over 200,000 Subjects Detects Novel Rare Variants, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility

Nima C. Emami, Taylor B. Cavazos, Sara R. Rashkin, Clinton L. Cario, Rebecca E. Graff, ..., Catherine Schaefer, Neil Risch, Thomas J. Hoffmann, Stephen K. Van Den Eeden, John S. Witte

Cold Spring Harbor Laboratory   ·   12 Feb 2020   ·   doi:10.1101/2020.02.12.929463

Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction

Linda Kachuri, Rebecca E. Graff, Karl Smith-Byrne, Travis J. Meyers, Sara R. Rashkin, Elad Ziv, John S. Witte, Mattias Johansson

Cold Spring Harbor Laboratory   ·   29 Jan 2020   ·   doi:10.1101/2020.01.28.922088

Cross-Cancer Evaluation of Polygenic Risk Scores for 17 Cancer Types in Two Large Cohorts

Rebecca E. Graff, Taylor B. Cavazos, Khanh K. Thai, Linda Kachuri, Sara R. Rashkin, ..., Eric Jorgenson, Thomas J. Hoffmann, Laurel A. Habel, John S. Witte, Lori C. Sakoda

Cold Spring Harbor Laboratory   ·   19 Jan 2020   ·   doi:10.1101/2020.01.18.911578

2018

Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers

Linda Kachuri, Olli Saarela, Stig Egil Bojesen, George Davey Smith, Geoffrey Liu, ..., Xuchen Zong, James D McKay, Paul Brennan, Christopher I Amos, Rayjean J Hung

International Journal of Epidemiology   ·   28 Jul 2018   ·   doi:10.1093/ije/dyy140

2017

Cancer risks in a population-based study of 70,570 agricultural workers: results from the Canadian census health and Environment cohort (CanCHEC)

Linda Kachuri, M. Anne Harris, Jill S. MacLeod, Michael Tjepkema, Paul A. Peters, Paul A. Demers

BMC Cancer   ·   19 May 2017   ·   doi:10.1186/s12885-017-3346-x

2016

Workplace exposure to diesel and gasoline engine exhausts and the risk of colorectal cancer in Canadian men

Linda Kachuri, Paul J. Villeneuve, Marie-Élise Parent, Kenneth C. Johnson, Shelley A. Harris

Environmental Health   ·   14 Jan 2016   ·   doi:10.1186/s12940-016-0088-1